Carvacrol Ameliorates DSS-Induced Intestinal Inflammation in Rats by Suppressing the TLR4/NF-κB Pathway
نویسندگان
چکیده
The present study aimed to explore the therapeutic effects of carvacrol on ulcerative colitis (UC) inflammation model induced by DSS (dextran sulfate sodium) in rats. Forty rats were randomly divided into blank, model, low-, middle-, and high-dose groups. drank 4.5% for 5 consecutive days induce UC except blank group. Different concentrations either or purified water supplied intragastric administration 7 assess protective effect involving TLR4/NF-κB signaling pathway. In vivo was found ameliorate symptoms Carvacrol significantly improved pathological group reduced DAI scores At same time, can reduce expression IL-6 TNF-α DSS, inhibit activation TLR4, hinder nuclear translocation NF-κB (P65), cleavage apoptosis-related protein cleaved-caspase 3, protect colon cell apoptosis. results vitro experiments showed that has a significant inhibitory apoptosis caused TLR4 LPS pcDNA3.1tlr4. Research revealed certain against inflammation-induced injury via inhibiting
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[This corrects the article DOI: 10.1155/2016/6421351.].
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ژورنال
عنوان ژورنال: Natural Product Communications
سال: 2022
ISSN: ['1555-9475', '1934-578X']
DOI: https://doi.org/10.1177/1934578x221130147